Unpacking the Pathogen Box—An Open Source Tool for Fighting Neglected Tropical Disease
来源期刊:ChemMedChemDOI:10.1002/cmdc.201800755
Ionic Liquids and Salts from Ibuprofen as Promising Innovative Formulations of an Old Drug
来源期刊:ChemMedChemDOI:10.1002/cmdc.201900040
Design of Natural‐Product‐Inspired Multitarget Ligands by Machine Learning
来源期刊:ChemMedChemDOI:10.1002/cmdc.201900097
Development of Fibrates as Important Scaffolds in Medicinal Chemistry
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A Novel Approach for Bisphosphonates: Ionic Liquids and Organic Salts from Zoledronic Acid
来源期刊:ChemMedChemDOI:10.1002/cmdc.201900397
H2O2‐Responsive Organosilica‐Doxorubicin Nanoparticles for Targeted Imaging and Killing of Cancer Cells Based on a Synthesized Silane‐Borate Precursor
来源期刊:ChemMedChemDOI:10.1002/cmdc.201900142
Bivalent SMAC Mimetics for Treating Cancer by Antagonizing Inhibitor of Apoptosis Proteins
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Structure−Activity Relationships of Cinnamate Ester Analogues as Potent Antiprotozoal Agents
来源期刊:ChemmedchemDOI:10.1002/cmdc.201900544
Six Laws of Open Source Drug Discovery
来源期刊:ChemmedchemDOI:10.1002/cmdc.201900565
Advancements in the Development of non‐BET Bromodomain Chemical Probes
来源期刊:ChemMedChemDOI:10.1002/cmdc.201800738
Highly Porous Hybrid Metal–Organic Nanoparticles Loaded with Gemcitabine Monophosphate: a Multimodal Approach to Improve Chemo‐ and Radiotherapy
来源期刊:ChemMedChemDOI:10.1002/cmdc.201900596
Poly[N‐(2‐hydroxypropyl)methacrylamide]‐Modified Magnetic γ‐F2O3 Nanoparticles Conjugated with Doxorubicin for Glioblastoma Treatment
来源期刊:ChemMedChemDOI:10.1002/cmdc.201900564
Experimental and Computational Evaluation of Piperonylic Acid Derived Hydrazones Bearing Isatin Moieties as Dual Inhibitors of Cholinesterases and Monoamine Oxidases
来源期刊:ChemMedChemDOI:10.1002/cmdc.201900277
Quinoline‐Conjugated Ruthenacarboranes: Toward Hybrid Drugs with a Dual Mode of Action
来源期刊:ChemmedchemDOI:10.1002/cmdc.201900349
Flexible Fragment Growing Boosts Potency of Quorum‐Sensing Inhibitors against Pseudomonas aeruginosa Virulence
来源期刊:ChemmedchemDOI:10.1002/cmdc.201900621
A Smart Nanotherapeutic Agent for in\u2005vitro and in\u2005vivo Reversal of Heavy‐Metal‐Induced Causality: Key Information from Optical Spectroscopy
来源期刊:ChemMedChemDOI:10.1002/cmdc.201900543
An Overview, Advantages and Therapeutic Potential of Nonpeptide Positive Allosteric Modulators of Glucagon‐Like Peptide‐1 Receptor
来源期刊:ChemMedChemDOI:10.1002/cmdc.201800699
Synthesis and Cytotoxicity of Octahydroepoxyisoindole‐7‐carboxylic Acids and Norcantharidin–Amide Hybrids as Norcantharidin Analogues
来源期刊:ChemMedChemDOI:10.1002/cmdc.201900180
A Two‐Step Multicomponent Synthetic Approach and Anti‐inflammatory Evaluation of N‐Substituted 2‐Oxopyrazines
来源期刊:ChemMedChemDOI:10.1002/cmdc.201800634
Chemical Space Overlap with Critical Protein–Protein Interface Residues in Commercial and Specialized Small‐Molecule Libraries
来源期刊:ChemMedChemDOI:10.1002/cmdc.201800537
Structure and energetics of ligand-fluorine interactions with galectin-3 backbone and side-chain amides - insight into solvation effects and multipolar interactions.
来源期刊:ChemMedChemDOI:10.2210/PDB6QLO/PDB
2‐Phenyloxazole‐4‐carboxamide as a Scaffold for Selective Inhibition of Human Monoamine Oxidase\u2005B
来源期刊:ChemMedChemDOI:10.1002/cmdc.201900261
Potential Therapeutic Effects of Mg/HCOOH Metal Organic Framework on Relieving Osteoarthritis
来源期刊:ChemMedChemDOI:10.1002/cmdc.201900546
Identifying Lysophosphatidic Acid Acyltransferase\u2005β (LPAAT‐β) as the Target of a Nanomolar Angiogenesis Inhibitor from a Phenotypic Screen Using the Polypharmacology Browser PPB2
来源期刊:ChemMedChemDOI:10.1002/cmdc.201800554
Substituted Aminoacetamides as Novel Leads for Malaria Treatment
来源期刊:ChemmedchemDOI:10.1002/cmdc.201900329
New Cyclams and Their Copper(II) and Iron(III) Complexes: Synthesis and Potential Application as Anticancer Agents
来源期刊:ChemMedChemDOI:10.1002/cmdc.201800702
Total Synthesis of the Endocannabinoid Uptake Inhibitor Guineensine and SAR Studies
来源期刊:ChemMedChemDOI:10.1002/cmdc.201900390
Potential Targets of Actein Identified by Systems Chemical Biology Methods
来源期刊:ChemMedChemDOI:10.1002/cmdc.201900499
Potent HIV‐1 Protease Inhibitors Containing Carboxylic and Boronic Acids: Effect on Enzyme Inhibition and Antiviral Activity and Protein‐Ligand X‐ray Structural Studies
来源期刊:ChemMedChemDOI:10.1002/cmdc.201900508
Fragment Growing to Design Optimized Inhibitors for Human Blood Group\u2005B Galactosyltransferase (GTB)
来源期刊:ChemMedChemDOI:10.1002/cmdc.201900296
Synthesis and Biological Evaluation of Nipecotic Acid and Guvacine Derived 1,3‐Disubstituted Allenes as Inhibitors of Murine GABA Transporter mGAT1
来源期刊:ChemMedChemDOI:10.1002/cmdc.201900170
Discovery and Pharmacophore Mapping of a Low‐Nanomolar Inhibitor of P. falciparum Growth
来源期刊:ChemMedChemDOI:10.1002/cmdc.201900526
Chiral Pool Synthesis, Biological Evaluation and Molecular Docking Studies of C‐Furanosidic LpxC Inhibitors
来源期刊:ChemMedChemDOI:10.1002/cmdc.201900068
Structure‐Based Design, Synthesis, and Biological Evaluation of Imidazo[4,5‐b]pyridin‐2‐one‐Based p38 MAP Kinase Inhibitors: Part 1
来源期刊:ChemMedChemDOI:10.1002/cmdc.201900129
Roles of the Conserved Amino Acid Residues in Reduced Human Defensin\u20055: Cysteine and Arginine Are Indispensable for Its Antibacterial Action and LPS Neutralization
来源期刊:ChemMedChemDOI:10.1002/cmdc.201900282
Ligand‐ and Structure‐Based Approaches of Escherichia coli FabI Inhibition by Triclosan Derivatives: From Chemical Similarity to Protein Dynamics Influence
来源期刊:ChemmedchemDOI:10.1002/cmdc.201900415
Microtubule‐Targeting 7‐Deazahypoxanthines Derived from Marine Alkaloid Rigidins: Exploration of the N3 and N9 Positions and Interaction with Multidrug‐Resistance Proteins
来源期刊:ChemMedChemDOI:10.1002/cmdc.201800658
The Application of Biomaterials in the Treatment of Platinum‐Resistant Ovarian Cancer
来源期刊:ChemMedChemDOI:10.1002/cmdc.201900450
Synthesis and Antiviral Evaluation of 3′‐Fluoro‐4′‐modified‐5′‐norcarbocyclic Nucleoside Phosphonates
来源期刊:ChemMedChemDOI:10.1002/cmdc.201800804
Oxidative Cyclization‐Induced Activation of a Phosphoinositide 3‐Kinase Inhibitor for Enhanced Selectivity of Cancer Chemotherapeutics
来源期刊:ChemMedChemDOI:10.1002/cmdc.201900481
Novel BQCA‐ and TBPB‐Derived M1 Receptor Hybrid Ligands: Orthosteric Carbachol Differentially Regulates Partial Agonism
来源期刊:ChemMedChemDOI:10.1002/cmdc.201900283
Targeting iNOS As a Valuable Strategy for the Therapy of Glioma
来源期刊:ChemMedChemDOI:10.1002/cmdc.201900580
Structure‐Based Screening of Tetrazolylhydrazide Inhibitors versus KDM4 Histone Demethylases
来源期刊:ChemmedchemDOI:10.1002/cmdc.201900441
Rational Adaptation of L3MBTL1 Inhibitors to Create Small‐Molecule Cbx7 Antagonists
来源期刊:ChemMedChemDOI:10.1002/cmdc.201900021
[18F]PRIMATX, a New Positron Emission Tomography Tracer for Imaging of Autotaxin in Lung Tissue and Tumor‐Bearing Mice
来源期刊:ChemMedChemDOI:10.1002/cmdc.201900297
Diamondoid Amino Acid‐Based Peptide Kinase\u2005A Inhibitor Analogues
来源期刊:ChemMedChemDOI:10.1002/cmdc.201800779
An Angle on MK2 Inhibition—Optimization and Evaluation of Prevention of Activation Inhibitors
来源期刊:ChemMedChemDOI:10.1002/cmdc.201900303
A New Lead Identification Strategy: Screening an sp3‐rich and Lead‐like Compound Library Composed of 7‐Azanorbornane Derivatives
来源期刊:ChemMedChemDOI:10.1002/cmdc.201900398
Divergent Synthesis and Evaluation of the in\u2005vitro Cytotoxicity Profiles of 3,4‐Ethylenedioxythiophenyl‐2‐propen‐1‐one Analogues
来源期刊:ChemMedChemDOI:10.1002/cmdc.201900225
Discovery of Novel Biased Opioid Receptor Ligands through Structure‐Based Pharmacophore Virtual Screening and Experiment
来源期刊:ChemMedChemDOI:10.1002/cmdc.201900418