JACC-Basic to Translational Science

Epigenetics in Cardiac Hypertrophy and Heart Failure

Extracellular Matrix From Hypertrophic Myocardium Provokes Impaired Twitch Dynamics in Healthy Cardiomyocytes

Cardiomyocyte SMAD4-Dependent TGF-β Signaling is Essential to Maintain Adult Heart Homeostasis

Cardiac Nuclear High-Mobility Group Box 1 Ameliorates Pathological Cardiac Hypertrophy by Inhibiting DNA Damage Response

CFTR Therapeutics Normalize Cerebral Perfusion Deficits in Mouse Models of Heart Failure and Subarachnoid Hemorrhage

Perioperatively Inhaled Hydrogen Gas Diminishes Neurologic Injury Following Experimental Circulatory Arrest in Swine

Alcohol Binge-Induced Cardiovascular Dysfunction Involves Endocannabinoid–CB1-R Signaling

Characterization of a Unique Form of Arrhythmic Cardiomyopathy Caused by Recessive Mutation in LEMD2

A Molecularly Detailed NaV1.5 Model Reveals a New Class I Antiarrhythmic Target

Cardiac Muscle Membrane Stabilization in Myocardial Reperfusion Injury

Celecoxib Is Associated With Dystrophic Calcification and Aortic Valve Stenosis

Angiopoietin-Like 3

Phase II Trials in Drug Development and Adaptive Trial Design.

Cardiac Myosin Binding Protein-C Phosphorylation Mitigates Age-Related Cardiac Dysfunction

Chest Compressions During Sustained Inflation During Cardiopulmonary Resuscitation in Newborn Infants Translating Evidence From Animal Studies to the Bedside

Bioactive Materials Facilitating Targeted Local Modulation of Inflammation

Gene Therapy Rescues Cardiac Dysfunction in Duchenne Muscular Dystrophy Mice by Elevating Cardiomyocyte Deoxy-Adenosine Triphosphate

Seipin Knockout Mice Develop Heart Failure With Preserved Ejection Fraction

Phosphorylation of Hsp20 Promotes Fibrotic Remodeling and Heart Failure

Overcoming Barriers to Development of Novel Therapies for Cardiovascular Disease

Quantification of DNA Damage in Heart Tissue as a Novel Prediction Tool for Therapeutic Prognosis of Patients With Dilated Cardiomyopathy

The Growing Case for Use of SGLT2i in Heart Failure

Limitations of Animal Studies for Predicting Toxicity in Clinical Trials

Deletion of Sulfonylurea Receptor 2 in the Adult Myocardium Enhances Cardiac Glucose Uptake and Is Cardioprotective

Modulation of Glucagon Signaling

Dipeptidyl Peptidase-4 Inhibition Prevents Vascular Calcification by Potentiating the Insulin-Like Growth Factor-1 Signaling Pathway

Adaptive Reductions in Left Ventricular Diastolic Compliance Protect the Heart From Stretch-Induced Stunning

Glucagon-Like Peptide-1–Mediated Cardioprotection Does Not Reduce Right Ventricular Stunning and Cumulative Ischemic Dysfunction After Coronary Balloon Occlusion

Cardioprotective Effects of VCP Modulator KUS121 in Murine and Porcine Models of Myocardial Infarction

The Hippo in the Clinic

Putting the Heat on Cardiac Fibrosis

Cardiac Versus Renal Response to Volume Expansion in Preclinical Systolic Dysfunction With PDEV Inhibition and BNP

DNA Damage Prediction Tool in Dilated Cardiomyopathy

The New Promise of Mitochondrial Transplantation for Myocardial Recovery∗

Empagliflozin and HFrEF

Connecting the Dots for Connective Tissue Growth Factor Roles in Cardiac Wound Healing After Myocardial Infarction∗

Empagliflozin and Protecting Microvascular Support of Heart Mechanics

It’s a SMAD, SMAD World

Nuclear Hmgb1

JACC: Basic to Translational Science

Paradoxical Cardiorenal Responses Following Acute Vasodilator/Natriuretic Treatment in Presystolic Heart Failure

Therapeutic Treatment Approaches Post–Myocardial Infarction

The Bslc2–/– Mouse

A Novel Mechanism to Explain Statin-Associated Skeletal Muscle Symptoms∗

JACC: Basic to Translational Science 2018 Young Author Award Winner

Scott Gottlieb’s Resignation as FDA Commissioner Is a Loss for Translational Medicine

Interleukin 5 Contributes to Human Atherosclerosis Development But not to Thrombotic Complications∗